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KMID : 0545120030130060998
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Journal of Microbiology and Biotechnology
2003 Volume.13 No. 6 p.998 ~ p.1000
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N-Acetylglycine Side Chain is Critical for the Antimicrobial Activity of Xanthostatin
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KIM, SI-KWAN
UBUKATA, MAKOTO/ISONO, KIYOSHI
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Abstract
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This study was carried out to elucidate the mode of bacteriostatic property of xanthostatin (XS), a novel depsipeptide antibiotic with an N-acetylglycine side chain and selective antimicrobial activity against Xanthomonas spp. Two biotransformed XSs were isolated by the treatment of XS with the cell lysate of Xanthomonas campestris pv. citri, a solvent partition. prepatative TLC, and HPLC. Structure determination of those two biotransformed XSs demonstrated deletion of the N-acetylglycine side chain. Notwworthily, they showed no antimicrobial activity against Xanthomonas spp. This result suggests that the N-acetylglycine side chain plays a criticla role in the antimicrobial activity of XS, and that the bacteriostatic porperty of XS is susceptibility of the easter bond between the hexadepsipeptide nucleus and the N-acetylglycine side chain to hydrolytic enzyme(s) produced by Xanthomonas spp.
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